SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

Product Name: SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
CAS No.: 165377-44-6
Chemical Name: SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE
Synonyms: SA-4503;CS-2246;SA-4503(2HCl);Cutamesine HCl;SA 4503;SA-4503;SA4503 >=98% (HPLC);Cutamesine hydrochloride;AGY94806 dihydrochloride;SA 4503 (dihydrochloride);Cutamesine dihydrochloride
CBNumber: CB91011619
Molecular Formula: C23H32N2O2.2ClH
Formula Weight: 441.44
MOL File: 165377-44-6.mol

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SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Property

Melting point:: 250-252°C
storage temp.: 2-8°C
solubility: Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
form: powder
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2181
Product name: SA4503
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2181
Product name: SA4503
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $424
Updated: 2024/03/01

Cayman Chemical

Product number: 26241
Product name: SA 4503
Packaging: 10mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 26241
Product name: SA 4503
Packaging: 50mg
Price: $322
Updated: 2024/03/01

Cayman Chemical

Product number: 26241
Product name: SA 4503
Packaging: 5mg
Price: $56
Updated: 2024/03/01

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SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

SA4503 (165377-44-6) is a potent and selective sigma 1 agonist (σ1 IC50?= 17.4 nM, σ2 IC50?= 1784 nM).1?It has been investigated as a cognition enhancer2,3, antidepressant4,5, anti-addiction agent6, and neuroprotectant7-10.

Uses

SA 4503 Dihydrochloride is a novel and selective σ1 receptor agonist.

Biochem/physiol Actions

SA4503 is a high affinity, orally active non-opioid intracellular receptor sigma-1 (σ1R) selective agonist (IC50 = 17.4 nM against 200 nM (+)-pentazocine for binding σ1R), exhibiting ~100-fold less affinity for the sigma 2 receptor subtype (σ2R) and little or no affinity toward 36 other receptors, ion channels and second messenger systems. Oral administration is reported to elicit cerebral acetylcholine (ACh) release in rat frontal cortex and hippocampus (5-20 mg/kg p.o.) and reduce immobility time in a mouse forced swimming test (Immobility time = 214.8 s without vs. 111.6 s with 1.0 mg/kg oral dosage).

storage

Desiccate at RT

References

1) Matsuno?et al.?(1996),?Binding properties of SA4503, a novel and selective sigma 1 receptor agonist; Eur. J. Pharmacol.?306?271 2) Matsuno?et al.?(1997),?SA4503, a novel cognition enhancer with sigma 1 agonistic properties; Behav. Brain Res.?83?221 3) Niitsu?et al.?(2012),?Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases; Curr. Pharm. Des.?18?875 4) Skuza and Rogoz?et al.?(2002),?A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist; Behav. Pharmacol.?13 537 5) Lucas?et al.?(2008),?Further evidence for an antidepressant potential of the selective sigma1 agonist SA4503: electrophysiological, morphological and behavioral studies; Int. J. Neuropsychopharmacol.?11?485 6) Mori?et al.?(2014),?Inhibitory effects of SA4503 on the rewarding effects of abused drugs; Addict. Biol.?19?362 7) Nakazawa?et al. (1998),?Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures; Neurochem. Int.?32?337 8) Ruscher?et al.?(2011),?The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke; Brain?134(Pt.3)?732 9) Ruscher?et al.?(2012),?Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride on inflammation after stroke; PLoS One.?7?e45118 10) Yamashita?et al.?(2015),?Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss; Int. J. Neurosci. Res.?93?788

SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE Suppliers

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View Lastest Price from SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE 165377-44-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

165377-44-6, SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDERelated Search:

SKF 96365 HYDROCHLORIDE 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid JZL 184 Nalmefene hydrochloride 2-Methoxyphenylacetic acid 4'-Hydroxyacetophenone Sodium benzoate PIPERAZINE DIHYDROCHLORIDE PIPERAZINE DIHYDROCHLORIDE SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE 1-(2-PHENYLETHYL)PIPERAZINE 1-(3-PHENYLPROPYL)PIPERAZINE

1-[2-(3,4-DiMethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride

SA-4503

SA-4503,1-(3,4-DIMETHOXYPHENETHYL)-4-(3-PHENYLPROPYL)PIPERAZINE DIHYDROCHLORIDE

1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride

1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine hydrochloride

SA-4503(2HCl)

Cutamesine HCl (SA-4503 HCl)

SA 4503 (dihydrochloride)

Cutamesine dihydrochloride

Cutamesine HCl

Cutamesine hydrochloride

SA4503; SA 4503; SA-4503; AGY94806; AGY-94806; AGY 94806; CUTAMESINE HCL; CUTAMESINE HYDROCHLORIDE

AGY94806 dihydrochloride

SA4503 DIHYDROCHLORIDE;AGY94806 DIHYDROCHLORIDE

CS-2246

SA 4503;SA-4503

SA4503 >=98% (HPLC)

1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazin...

165377-44-6

C23H32N2O22HCl

C23H34Cl2N2O2

C23H32N2O22ClH